• Clinical significance of disseminated tumour cells in non-small cell lung cancer 

      Rud, Ane Kristine Kongsgaard; Borgen, Elin; Mælandsmo, Gunhild; Flatmark, Kjersti; Le, Hang Ngoc Thi; Josefsen, Dag; Solvoll, Ingjerd; Schirmer, Cecilie; Helland, Åslaug; Jørgensen, Lars Hilmar; Brustugun, Odd Terje; Fodstad, Øystein; Boye, Kjetil (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-08-13)
      Background: Early-stage non-small cell lung cancer (NSCLC) patients have a high risk of disease relapse despite curatively intended surgical resection, and the detection of tumour cells in the bone marrow could be one method of determining the presence of the disseminated disease in its early stages.<p> <p>Methods: Bone marrow aspirates were collected from 296 patients at the time of surgery, and ...
    • EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal cancer 

      Boye, Kjetil; Nesland, Jahn M; Sandstad, Berit; Haugen, Mads Haugland; Mælandsmo, Gunhild; Flatmark, Kjersti (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-07-10)
      BACKGROUND: Proteolytic enzymes and their regulators have important biological roles in colorectal cancer by stimulating invasion and metastasis, which makes these factors attractive as potential prognostic biomarkers. METHODS: The expression of extracellular matrix metalloproteinase inducer (EMMPRIN) was characterised using immunohistochemistry in primary tumours from a cohort of 277 prospectively ...